This is supported by clinical reports showing tolerability, activity, and increased CSF penetration with high-dose HER-family small molecule TKIs in lung cancer patients [ 79, 80], suggesting that CNS activity of small molecule HER2-targeted therapies may be optimized through alternate dosing strategies.
The Holonic architecture has some unique features by which the objective of the DORPC problem could be optimized through a timely proposed strategy.
In order to maximize the performance of the SVM algorithm, the two parameters in the RBF kernel were preliminarily optimized through a grid search strategy, as briefed as follows.
For the application of modelling the arterial pulses, the advantage of using TSPSO is that, after the gross searching stage, the three Gaussian functions could be optimized through single dimension searching strategy, resulting in significantly shorter computation time.
The SVR parameter is optimized through three different optimization strategies.
A synthetic strategy was optimized through subsequent steps of MWCNTs functionalization and dispersion in a polymer matrix, by first reacting functionalized MWCNTs, 1,2,3,4-butanetetracarboxylic 1,2,3,4-butanetetracarboxylicl (PVacidand then adding a polyacrylic resin.
Often, however, a player's utility is optimized through use of a mixed strategy, in which she flips a weighted coin amongst several possible actions.
Target parameters of the same vowel optimized through the analysis-by-synthesis strategy are averaged together across multiple contexts as the underlying representation of that vowel.
This hinges on an appropriate sample size (in total and within each age strata) and a PK/PD sampling strategy that is optimized through simulation and incorporates alternative constructs, which are appropriate for each pediatric subpopulation.
Key parameters are optimized through numerical simulations.
Parameters were further optimized through back analysis.
