The achievement, from Demidov's perspective, was the "knowledge of what to do with this information once it had been obtained".
Therapeutic efficacy studies should only be performed once evidence has been obtained that the drug has a suitable pharmacokinetic profile to allow it to reach active concentrations within the tumour tissue.
Once this understanding has been obtained, it is not too painful to work up and down the hierarchy to fill it out; going up to other key result areas, charters, policies, missions, and even grand designs, and down to long-range plans, strategic programs, budgets, and short-term programs.
We start by optimizing Equation (6) for a relatively large value of λ(λ = 0.4), and once convergence has been obtained, we use the result as the starting point for a new optimization, this time with λ = 0.2.
Once approval has been obtained from the Parliament the Commissioners can take office.
Once consent has been obtained, patients are observed.
Once consent has been obtained, the baseline assessment is completed as part of the initial visit.
Once consent has been obtained, baseline assessments will be undertaken within 3 months of recruitment.
Once consent has been obtained, the participants will be enrolled in the program and their baseline information collected.
Once consent has been obtained, the baseline assessment will be conducted and participants will then be randomised to either the exercise intervention or control group.
