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Once discontinued, quinacrine was completely eliminated from plasma, with no drug detectable within one week.
The claims, once discontinued, could not be reinstated on the same legal and factual basis if new supporting evidence emerged.
Key point: Once discontinued, retreatment with omalizumab has a good response rate.
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Antimicrobial therapy was once again discontinued.
Patients experiencing grade >2 toxicity with sunitinib 12.5 mg once daily discontinued the treatment and went off-study.
Fluoxetine (20 mg/day) was administered again, in the middle of the third year of treatment, for a period of a few weeks; but the situation regarding weight gain did not improve and the drug was once more discontinued.
Once patients discontinue their specific osteoporosis medication, some will switch to another anti-osteoporotic treatment.
Fluid boluses should be discontinued once the patient is no longer fluid-responsive or the EVLWI has increased significantly.
Intubation was discontinued once spontaneous breathing resumed, and the mouse was allowed to recover on a heated platform.
In a randomly mating population, underdominant systems accelerate introgression of desired alleles and allow the release of individuals to be discontinued once the frequency of transgenic alleles attains a threshold.
In the present study, the cell growth rate and fatty acids production upon aeration rate indicated that higher cell quantity and large amount of fatty acids could be produced under moderate light conditions, whereas fatty acids synthesis was discontinued once approaching the stationary phase and the content decreased during the apoptosis phase (Table 1; Figs. 6, 7).
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