He seemed intent on signalling that he was in the know, a man of the world.
Introducing a new material into the tread/top of rail interface can raise questions about the impact on signalling systems.
The authors show that resting TReg cells are highly dependent on IL-2 for survival, whereas effector TReg cells are dependent on signalling through ICOS.
In this paper, the authors show that entry of lymphocytes to the white pulp depends on signalling through G-protein-coupled receptors.
In addition, the ability of A83 to expand eGFP cells in culture was dependent on signalling from the mitogen-activated protein kinase kinase (MEK) as treatment with a MEK inhibitor, PD0325901, abolished this effect.
In addition to the dynamic effects described above, calcium ions also may have static effects on signalling.
Yet, many studies on signalling systems focus exclusively on the sender, and often ignore the receiver side and the ecological conditions under which signals evolve.
Having established interactions between Themis2 and several signalling components we wondered whether Themis2 might impact on signalling pathways in which these proteins are implicated.
Finally, we observed that the differentiating cells passed through 'exit gates' after which point they were no longer dependent on signalling from inducing molecules for Mixl1 expression.
Notably, contrasting results with respect to theoretical expectations were obtained when studying the effects of sexual selection on signalling in small populations [8], [9].
Finally, we demonstrated that the differentiating cells passed through 'exit gates' after which point they were no longer dependent on signalling from inducing molecules for Mixl1 expression.
