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Implementation of an evidence-based IIT guideline improves blood glucose control, with results comparable with the original studies on IIT in Leuven.
The use of a multiport infusion device with a limited dead volume could limit hypoglycemia in patients on IIT.
The present study suggests that for patients on IIT and receiving multiple medications through complex infusion tubing, blood glucose variations may occur after interventions involving the infusion tubing, in the absence of any change in insulin infusion rate.
Further research will permit analysis of additional parameters to evaluate BG profiles and BG variability, which will improve the quality of studies on IIT.
A large study on IIT was stopped prematurely due to high incidence of severe hypoglycemia (SH) (blood glucose level (BGL) <40 mg/dl) [ 3].
This was a pre-planned analysis of all 700 pediatric critically ill patients included in a prospective, randomized, controlled study on IIT [ 1].
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Further analyses are needed to link the positive effect of IIT on mitochondrial integrity to an effect on oxidative stress state in critical illness.
This reduction partially explained the beneficial effect of IIT on prolonged MV.
The effects of IIT on adiponectin and RBP4 are indicative of altered insulin sensitivy with IIT in the ICU patients.
MVLR confirmed the independent protective effect of IIT on prolonged MV (p = 0.002, OR:0.40 (95% CI: 0.22 0.72)).
MVLR confirmed the independent protective effect of IIT on prolonged MV (P = 0.03, OR = 0.55 (95% CI = 0.31 0.95)).
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