We applied the same procedure to global subduction zones and found that slip-deficient stick slip patches with large spatial extents (equivalent to the rupture area of M9-class earthquakes) occur in an additional 25 locations.
In order to determine if the correlation between CI level and Hira expression occurs in additional combinations of Wolbachia and their hosts, we examined Hira expression in D. simulans infected with wRi and wAu.
We further eliminated 28 of the remaining 32 SNPs as candidate mutations, since they occurred in additional controls tested.
Thus, both truncation of CRR21 and loss of the ndhD C383 editing site target have occurred in additional examples in angiosperm evolution, and these truncated CRR21 genes appear to be maintained under strong negative selection.
The characterisation of alterations occurring in additional candidate genes (NRAS, BRAF, PIK3CA, PTEN) may increase the negative predictive value up to 70%, but it is not sufficient to identify all resistant cases (De Roock et al, 2010; Blanke et al, 2011; Van Cutsem et al, 2011; www.ema.europa.eu; www.fda.gov).
Such genes only occur once in Additional file 1 and the tables presented in this paper, but the references to and discussion of such genes will highlight their pleiotropic functions.
Large-scale submarine landslides discovered off the coast of Florida have lent significant support to the hypothesis, although such landslides would have had to occur in many additional locations to provide enough methane to cause the PETM.
Thus, on chromosome 4, seven translocations (Trans) and inverted translocations (Inv-Trans) between the nucleotides 19,153,501 and 27,502,845, in addition to four inverted duplications (Inv-Dup) have occurred (details in Additional file 5, sheet F8_Exclusive).
However, another DLT occurred in these additional patients, thus we de-escalated to dose level 1, enrolling an additional three patients to confirm the MTD.
