Notably, mammary tumors were infrequent events, but developed in multiparous WAP-Brk mice at a three-fold higher incidence relative to wild-type mice (Table 1); this trend failed to reach statistical significance.
Notably, RB1CC1 biallelic mutation was significantly infrequent (two of 38 cases, 5.3%) relative to the expected frequency based upon mutant allele incidence (13.6%, five of 38 cases; Fisher's exact test p value, 0.01).
Gain of 2p has been reported as a relatively infrequent event in MGCTs of childhood, notably YSTs (Rickert et al, 2000; Schneider et al, 2002), but the association with 12p gain may be particularly relevant.
Notably, DUX4 expression in FSHD-derived cells is extraordinarily infrequent.
Negative perceptions (e.g., swelling and edema) seem to be infrequent, increase with long-term therapy and, notably, to be estrogen-related.
Genome-wide methylation differed in colorectal carcinomas belonging to distinct CpG island methylation phenotype (CIMP) groups, most notably in the ones with associated microsatellite instability (MSI), where hypomethylation was infrequent compared to both CIMP+/MSI-and CIMP-/MSI-groups.
Notably, all approaches except direct observation manipulate the system in order to detect events that are very infrequent.
Mutations in the RAS genes were extremely infrequent (HRAS, n = 1/60, with no mutations in KRAS and NRAS) and mutations in EGFR notably absent.
While their fashion choices may have had a more widespread impact than their music (most notably on the hair-metal scene of the eighties), it's difficult to justify missing one of this iconic band's infrequent, high-energy reunion gigs.
PROFANITY -- Mild and infrequent.
