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The risk of DCIS progressing to invasive carcinoma is not well ascertained and robust biomarkers capable of stratifying the most aggressive from the more benign forms of the disease are currently lacking.
They include genetic variants that are not well ascertained with the current GWAS and interactions between genetic variants, and between genetic and environmental factors that are beyond the analysis and design of current studies.
However, its clinical usefulness is not well ascertained and currently WT1 is neither used for risk stratification of newly diagnosed AML patients, nor used to give different therapeutic strategies.
Although it is not well ascertained if these proteins belong to the proinflammatory pathway of oedema or rather if they play a protective anti-inflammatory role, certainly this is a root to figure out if by rating the expression of IGF and its binding proteins the time of posttraumatic oedema formation and all its sequelae could be monitored.
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RP is not well-ascertained by healthcare providers; in contrast, patient-reported QOL outcomes appear to be a powerful tool to capture pulmonary toxicity outcomes [ 9].
Although the association between FGF-23 and mortality is well ascertained in the CKD population, underlining mechanisms remain not well known yet.
I could wish to have that point well ascertained with respect to any man so employed".
However, the data ascertained at various CDCs may not well capture the real epidemiological scenarios for human rabies in China.
We used a one year follow-up period to ascertain mortality because postoperative cardiac complications are not well captured by administrative databases but are closely associated with increased long term mortality.
We excluded books, chapters, commentaries and reviews whose methodology was not systematic or reviews whose methodology could not be ascertained, as well as systematic reviews that did not directly address effectiveness, e.g. those looking at patient acceptability or drop-out alone.
Even though cost-effectiveness analysis within health technology assessment has long been recognized as a compelling way to ascertain value for buyers, its role in the allocation of research and development by companies is not well described.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com