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indicated this loss of information is not a substantial issue.
Both plots and tests indicated that publication bias in our meta-analysis was not a substantial issue.
But I always recognize that what I learn is not a substantial issue.
This is not a substantial issue for linear normalization, which is mostly driven by a large contrast change at the outside boundary of the brain, but the blurred internal structures could easily confuse high-dimensional non-linear registration [21].
Also, high agreement between parent reports and GP records suggest that missing historic diagnoses were not a substantial issue.
Moreover, the absence of an overall increase of cancer compared to rates from two different registries suggests that over-reporting was not a substantial issue with the caveat that conclusions from registry comparisons are limited by differences in geographic coverage and study period.
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"But there's a substantial issue about my client's mental state".
This is a substantial issue requiring attention.
When assessing imported malaria cases, underreporting is a substantial issue.
Illicit drug use for recreational purposes is a substantial issue within Western society and causes significant health issues.
Not a truly substantial issue, but it bothered me.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com