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To achieve an optimal NO availability, approaches including NO donors or inhibitors may be useful.
Photocontrollable NO donors enable precise spatiotemporal release of NO under physiological conditions.
Furthermore, NO donors cause acute moderate pain in humans, suggesting a role in acute nociception [14].
Cultured primary sensory neurons display both TRPV1- and TRPA1-dependent responses to NO donors.
We demonstrate that NO donors directly activate TRPV1 and TRPA1 in isolated inside-out patch recordings.
We next sought to identify the molecular target(s) of NO donors within DRG neurons.
Both NO donors also reduced a4b7-dependent lymphocyte endothelial adhesion.
The crucial exogenous source of NO is the NO donors.
In IFM, the NO donors decreased ROS production.
While NO donors are not currently used for treatment of IBD, the literature and our data here suggest that NO donors could be beneficial.
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Nitric Oxide (NO) generation from endogenous NO-donors catalyzed by diselenide modified biomaterials has been reported.
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