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Specifically, elevated levels of NO disrupt the redox activity of protein-disulfide isomerase, a key endoplasmic reticulum-resident chaperone by S-nitroso modification of its redox-active cysteines.
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Thought we talked about this folks, no disrupting traffic.
Flitch also tweeted: "We talked about this folks, no disrupting traffic" — a comment which was promptly ridiculed on social media.
We observed that the interrupted PPE genes were PPE16, PPE34, PPE38, PPE40 and PPE49 in several points and in both orientations and there were no disrupted PE genes (Additional file 1: Table S4).
Examples of more reliable reconstructions of nuclear receptors have been published, e.g. the ancestor of MR and GR (mineralocortoid and glucocorticoid receptors) in which the overall accuracy of the LBD was above 99%, with no disrupting mutation at any site [ 71].
Nitric oxide (NO) can disrupt tight junctions and gap junctions, and NO and NO synthases (NOS1 NOS3) were upregulated in mutant white matter.
Because higher ω in Cercopithecinae can be taken as a signal of neutral evolution we simulated neutral evolution using ReEVOLVER 1.0 [30] and found that it is very unlikely to observe no disrupting mutations in Cercopithecinae TAAR4 orthologs (Pdis = 0.0006) within 55 myr of neutral evolution (or 7.2 synonymous substitutions, respectively).
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