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My Pathways is a graphical representation of the biological relationships between gene products, which are supported by at least one reference from the literature, from a textbook, or from canonical information stored in the Ingenuity Pathways Knowledge Base.
Now where's my Pathways Into Darkness?!
I now see that many of my pathways are closed.
Optional Analyses: My Pathways My List.
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The transcription factor's (TF's) downstream targets were identified in Ingenuity by adding the TF to "my pathway page".
Finally, we used the Connect function from IPA My Pathway toolbox to connect the commonly shared genes of the three phenotypes to the signaling network involved in neuronal adaptation/plasticity in substance addiction [ 17, 18].
Connect function from IPA My Pathway toolbox showed that DRD2 is the gene common to both the list of genetic variations associated with all three addiction phenotypes and the components of the brain neuronal signaling network involved in substance addiction.
Finally, in order to understand the biological context of the gene network (association of genetic variations with addiction to opioids, alcohol and nicotine), we used the Connect function from IPA My Pathway toolbox to connect the commonly shared genes of three phenotypes to the signaling network involved in neuronal adaptation/plasticity in substance addiction [ 17, 18].
With my Pathway results I opened a PDF and discovered the results before I really understood what they meant.
The answer was a resounding and electrifying YES! My pathway to Molière's famous farce, Tartuffe, has taken a strange and winding course.
I'm not exactly clear on my pathway out of this, and I don't expect divine intervention to part these roiling seas for me; but, I do know that the very first step is deciding, as I have, that I really, truly deserve to be free of this.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com