Sentence examples similar to Mutation load hypothesis from inspiring English sources

Across cancer types, global enhancer activity was positively associated with aneuploidy, but not mutation load, suggesting a hypothesis centered on "chromatin-state" to explain their interplay.

Mutation load was calculated as described [ 40, 41].

The high similarity of estimates available for the mutation load in T. thermophila also strengthens the hypothesis that the mechanism responsible for the accumulation of deleterious effects is dependent on a species-specific feature such as chromosomal copy number.

The second possibility is the mutation load.

34 Furthermore, the expression patterns in the murine organ of Corti and spiral ganglion cells have led to the hypothesis that progressive hearing loss could be a result of increasing mutation load toward the apex of the inner hair cells and neurons of the spiral ganglion, resulting in accumulation of defective proteins and, ultimately, a negative effect on cochlear function.

In contrast, the sexual conflict hypothesis predicts the opposite chromosomal distribution, with more cytonuclear genes occurring on autosomes to alleviate mutation load in males.

This hypothesis may also explain the dichotomous behavior between ER+ and ER− breast tumors with respect to mutation load.

To obtain insight into the mutation load in specific genes ensuing differentiation and proliferation in SCs, we mapped our mutations to expression data generated by the FANTOM5 project28.

p53 mutations are frequent in tobacco-related cancers and the mutation load is often higher in cancers from smokers than from nonsmokers.

Our results support the cognitive load hypothesis for lying, yet are mixed regarding the response conflict hypothesis.

Absolute mutation load can range from zero (no load) to ten in our simulations.