Sentence examples for Mutation accumulation theory from inspiring English sources

They are based on the mutation accumulation theory of half a century ago.

Genomic regions exhibiting high D, but low recombination rates, are therefore good candidates for harboring variants implicated under the mutation accumulation theory of ageing.

Under the mutation accumulation theory, the persistence of asexual lineages is more problematic unless asexuals are able to minimise the competition with sexuals through high dispersal rates [ 17].

Diverse theories have been proposed in an attempt to explain this issue [ 11], including the mutation accumulation theory, suggested in 1952 by Medawar [ 86], and the antagonistic pleiotropy theory, suggested by Williams in 1957 [ 87].

Charlesworth, B. Patterns of age-specific means and genetic variances of mortality rates predicted by the mutation-accumulation theory of ageing.

Mechanisms of aging and longevity were selected based on major theories of aging, such as the theory of mutation accumulation, the theory of programmed cell death, etc. [ 4 ].

This observation is also notable in the context of the mutation accumulation evolutionary theory of ageing, which posits that unconditionally deleterious alleles can accumulate if their fitness effects are confined to postreproductive periods of life when selection against them is weak (Medawar 1952; Charlesworth 1994).

This observation harmonizes with the mutation accumulation evolutionary theory of aging, based on the idea that unconditionally deleterious alleles can accumulate if their fitness effects strike only in the postreproductive phase of life.

Lansing (1947, 1954) hypothesized that the cumulative aging effect across generations was caused by a factor that accumulates during an individual's life and is transmitted to the next generation, an idea compatible with both mutation accumulation and antagonistic pleiotropy theories.

These theories assume therefore that mutations increasing mortality late in life are either subject: 1) to very small negative selection and can therefore accumulate (mutation accumulation) or 2) to small enough negative selection to be traded-off against higher fertility or survival at young ages (antagonistic pleiotropy).

In this respect, our results therefore provide support for the theory of mutation accumulation.