Despite their cellular abundance, vault function remains elusive although they have been linked to many cellular processes including the innate immune response, multidrug resistance in cancer cells, multifaceted signaling pathways, and intracellular transport [6].
Network interactions can be mapped by using systems biology strategies that, in contrast to a single pathway approach, integrate multifaceted analyses to provide a global and dynamic perspective of cellular responses [28], [29].
The clinical significance of IFN-I pathway activation in SLE is multifaceted.
For instance, ROS play multifaceted roles as a "molecular switch" in the regulation of several core autophagic pathways (e.g., ATG4-ATG8/LC3, Beclin-1, p53N, PI3K-Akt-mTOR-mTOR, and MAPK signaling) that may jointly seal the fate of cancer cells.
The pathways leading to criminal behaviour and, not the least, to mortality are multifaceted and involve a complex interplay between family psychosocial characteristics and individual problems in the developmental context.
Such multifaceted targeting was also observed by Uhlmann et al., investigating the EGFR-driven cell cycle pathway in MDA-MB-231 breast cancer cells [ 35].
tPA has multifaceted effects on tissue; it interacts with parenchymal cells through proteolytic plasminogen or non-plasminogen pathways [44] [47].
Multifaceted interventions which incorporate all staff and facilitate organisational adaptations must be seriously considered and incorporated alongside care pathways in a continuous manner.
Certainly the problem is multifaceted.
Copepods lack compound (i.e., multifaceted) eyes.
