In 1968, The Lancet published the results of a modest trial of what is now regarded as among the most important medical advances of the twentieth century.
Analyses of time to progression or response rate surrogate endpoints, measures that do not include a survival in the surrogate, report more modest trial-level associations.
With the modest trial selection parameters chosen here, almost all patients who tolerated full-course treatment had preserved weight and performance status, and controlled pain over the study period (not shown).
He said that if the suit brings any changes, they would affect specific buildings, and "the effect would be very modest". No trial date was set as of mid-August.
If six months doesn't sound like a lot, consider the economic incentive here: for the price of a modest clinical trial in children (costing at most $3 million), Schering can extend the life of its basic patent half a year and earn close to $1billion.
Evidence defining treatment for HIV-infected persons and for pregnant women is limited, but available data support penicillin as first-line therapy.The mainstay of syphilis treatment is parenteral penicillin G despite the relatively modest clinical trial data that support its use.
Usually, information is fragmented across many small or modest-sized trials, with selective publication and reporting.
However, a 10-year follow-up identified modest post-trial risk reductions [ 42], again suggesting a delayed benefit.
The present meta-regression analysis aims to shed light on this specific point, by increasing statistical power and enhancing the precision of estimates across multiple modest-size trials.
However, there was also a modest reduction in trial-to-trial failure rates after SWE-induced plasticity if compared with the undeprived control, and this was also found to be stimulus intensity-dependent (Fig. 5A and B).
