In neuroscience it is difficult to overstate the importance of the Hodgkin–Huxley model of action potentials or Rall's use of cable theory to provide a framework for understanding the complex, dendritic structures of neurons.
As the stimulus amplitude was further increased in the model, bursts of action potentials disappeared and single spike action potentials were elicited as shown in Figure 2A (bottom panel).
Integrating these empirical results in computational models of action potential dynamics at the membrane of a cortical neuron, we specify the functional effects of the mutation and describe a mechanism that leads to temperature-sensitive epilepsy.
Some of the more powerful examples are the Hodgkin-Huxley model of action potential propagation, Hebbian-based plasticity rules, Barlow's efficient coding hypothesis and Marr's three levels of analysis.
MMOs are a class of complex oscillations occurring in excitable systems and in particular in models of action potential generation in neurons, see [21] for a review.
DOI: http://dx.doi.org/10.7554/eLife.04057.006 To explore the mechanisms underlying the paradoxical [Ca2+]o independence of the TCR, we used a realistic model of action potential-dependent transmitter release (Eggermann and Jonas, 2012; Figure 3).
Hodgkin and Huxley's (HH) model for the generation and propagation of action potentials along the giant axon of the squid Loligo lies at the foundations of modern neuroscience [22, 30].
SENB simulates the propagation of action potentials along a model of an unmyelinated axon with electrical conduction properties like the squid giant axon.
First, the onset of action potentials in the model is much slower than observed in the experimental data, consistent with previous reports of 'kink'-like spike initiation (Naundorf et al. 2006; McCormick et al. 2007).
The first is the conversion of postsynaptic potentials (PSP) into an average density of action potentials (AP) which is modeled using a sigmoid function.
Topics covered include passive electrical properties, composition of action potentials, trains of action potentials, multicompartment modeling, and research topics.
