Sentence examples for Mitotic checkpoint activation from inspiring English sources

However, nicotine treatment appeared to play no role in nocodazole-induced mitotic checkpoint activation.

Here, we have investigated the nature of condensin function in human centromeres, including structure of both inner and outer kinetochores, microtubule attachment, and mitotic checkpoint activation and silencing.

Like the mutant male PGCs, the mutant female PGCs with abnormal nuclei adapted to sustained mitotic checkpoint activation featured with abnormal Aurora B staining [28] (Figures S2A & B).

Condensin-depleted metazoan cells enter anaphase accompanied by chromosome missegregation [11], [20], [24], [25], an outcome in apparent contrast with yeast conditional condensin mutants, where mitotic checkpoint activation protects chromosomes from missegregation and is essential for recovery after cells return to permissive conditions [18].

Results showed increased levels of both of these proteins in early HCV that is suggestive of mitotic checkpoint activation or mitotic arrest in the liver cells.

Consistent with this notion, we found that 80% of Cik11 521 cells arrested as large budded cells upon shift to the restrictive temperature, indicative of mitotic checkpoint activation.

Inefficient activation of Mps1 results in weakened mitotic checkpoint activity and the persistence of falsely attached chromosomes, causing frequent but non-lethal chromosome segregation errors [16].

If sister chromatid cohesion defect is the cause of the massive loss of progenitor cells in Esco2-deficient neuroepithelium, we should observe an increase in the number of mitotic cells as a result of mitotic spindle checkpoint activation (Peters et al, 2008).

Cells exposed to low concentrations of taxol may undergo a mitotic arrest either by checkpoint activation or by mechanical disruption of microtubules.

Tim depletion did not activate mitotic checkpoint protein BubR1, and prevented the normal activation of BubR1 after nocodazole treatment [47] (Fig. S6B).

Checkpoint activation in mitotic germ cells arrests cell cycle progression but not cellular growth, resulting in enlargement of the mitotic germ cells (Ahmed and Hodgkin 2000).