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This could involve running a full program in two carefully selected settings and using minimal outcomes to test its efficacy, such as cognitive and quality of life measures.
Clear guidelines on undergraduate medical curriculum has been given by the General Medical Council (GMC) of the United Kingdom in Tomorrow's Doctors 2009 on the expected minimal outcomes with regards to drug therapy (such as an understanding of adverse effects and harmful drug interactions) [ 15].
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In general, barriers to guideline adherence consist of a lack of awareness, a lack of agreement or perceived self-efficacy to change, minimal outcome expectancy, and inertia associated with a lack of faith in existing treatment practices [ 27].
A recent systematic review of the literature identified barriers to guideline adherence, including a lack of: awareness, agreement, or perceived self-efficacy to change; minimal outcome expectancy; and an inertia associated with faith in existing treatment practices [ 13].
Consistent with the correlation analyses (Fig. 5), while the initialization location sets and the radius of seed ROI had a minimal outcome on RSFC-Snowballing aggregate peak density map values (no voxels exhibited a significant main effect), the choice of the number of zones and threshold for neighbor correlation had a greater impact (Fig. 6).
Administration of age-group or randomly targeted 50% effective pre-pandemic vaccine with 7% population coverage (current US H5N1 vaccine stockpile) had minimal effect on outcomes.
29 The number of baseline primary PI mutations, as identified by the IAS-USA had minimal effect on virologic outcomes, as patients with 0 mutations in the TITAN trial achieved suppression in 84% (139/165) as did patients with ≥3 baseline mutations.
Surgical treatment and adjuvant therapeutic modalities such as chemo- and radiotherapy have only a minimal effect on patient outcome and the overall 5-years survival rate is less than 25%.
When the impact of the errors is considered with regard to timing and location for inpatient deaths, it was only in the operating theatre that most errors were thought to have minimal effect on the outcome (Fig. 2).
We reasoned that identified duplicated genes could be simply genes free to duplicate with minimal negative outcomes.
Parents described feeling blamed and thus being resistant to treatment while simultaneously having low treatment expectations due to experiencing minimal positive outcomes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com