Consistent with this, direct comparison of the wild-type versus JAK2V617F bone marrow cells in competitive transplantation experiments demonstrated that JAK2V617F confers a mild but significant disadvantage to HSCs, an effect that was most striking in secondary transplantations.
To address these disadvantages, mild processing methods (i.e., processing technologies for food preservation that apply mild temperature; <40 °C) aiming to destroy microbial food contaminants have been developed.
The disadvantage of mild trypsin treatment to isolate 'pure' ICM cells, is that TE and ICM cannot be compared from the same embryo and that the trypsin treatment by itself may cause a difference in gene expression.
Importantly, just as any biomaterial, stainless steel too possesses certain disadvantages such as mild corrosion and mismatch of physical properties with the soft tissue adjacent to the bone.
By combining these four items, we defined an index with five levels of labour market disadvantage, ranging from "none", "mild", "moderate", "severe" to "very severe" disadvantage.
If you have a philosophical aversion to using baking soda, you may use mild brine, which would present the disadvantage of drawing out nutrients and vitamins from your peppers.
We chose this decision because it is a common problem of broad interest and many patients prefer not to take treatment for mild hypertension if the advantages and disadvantages are explained [17].
Although this influence affords moderately warm summers and mild winters, it is accompanied by the disadvantages of high humidities, extended stretches of rainfall, and, in the cooler seasons, fog.
These data cumulatively suggest that the selective disadvantage that breast cancer lines experience following mild hyperthermic shock may be due to an inability to correctly regulate their core biological processes and mitotic cell cycle machinery.
