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Mice were developed using 129/Sv ES cells cloned into Alb-Cre transgenic mice having a B6 background (B6.Cg-Tg(Alb-cre)21Mgn/J) and backcrossed six times to B6.
Tg UGT1A1*28 Ugt1−/− (hUGT1) mice were developed previously in a C57BL/6 baC57BL/6d23,24.
Experiments using mice were developed through an approved Institutional Animal Care and Use Committee (IACUC) protocol (IS00004043) and an active Institutional Biosafety Committee IBCC) study (#1385), both reviewed by the Integrity and Compliance board at the University of South Florida and Moffitt Cancer Center.
Using selective bi-directional breeding procedures, two different lines of mice were developed.
Transgenic mice were developed that express mouse ERΔ3 in all tissues examined, including the mammary gland.
Grn-KO mice were developed as an FTLD model, but lack cortical TDP-43 mislocalization and neurodegeneration.
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Mice from her farm were developed into the common laboratory strains known as DBA and C57BL.
Mice-bearing bilateral tumors were developed by subcutaneous injection of cancer cells on the bilateral dorsal flank regions using a sterile syringe with a 28-gauge needle.
Mice knockout models have been developed for each ligand and receptor, and conditional alleles have been generated for VEGF-A, Flt-1 and Kdr.
Mice deficient for Atg5 specifically in neural cells have also been developed and analysed.
Mice that model mitochondrial dysfunction and Alzheimers disease have only recently been developed [26], [27].
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