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However, these disadvantages do not seem to impose serious limitations because the modeling approach presented here can be potentially extended to more general delivery/collection geometries as well as multilayer tissue geometries by following a similar methodology in model development.
PG performed the simulations, data synthesis and interpretation and wrote the manuscript, WMP provided assistance in model development and methodology, KH provided regional GCM outputs.
In this review we introduce methodology to resolve metabolic fluxes from stable isotope labeling and relevant techniques in model development, model simplification, flux uncertainty analysis and experimental design that together is termed metabolic flux analysis.
The presented MINLP-based optimization approach for nested-model selection and identification is a powerful methodology for model development in systems biology.
The overall methodology for model development is depicted in Fig. 1.
Open image in new window Fig. 2 Basic methodology of model development by ANN.
Our work advances existing systems pharmacology modeling methodologies and illustrates model development strategies with particular focus on integrating the role of cell signaling networks in disease.
The methodology in Chapter 2, Model development and validation methodology: a classical big data application, is used to evaluate and rank the models indicating which six models are recommended for future use.
For each of the 20 drugs of the analysis set of the completeness of the model, their evaluation reports and the SPCs were analyzed using the same methodology as in the model development.
Specifically, her interest in statistical methodology covers hierarchical model development, variable selection, model averaging, predictive modeling and the analysis of large complex datasets.
Researchers and reviewers, who are collectively in charge of model development, care more about the methodology and reproducibility issues than the ease of use.
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