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Supplementary Figure 3 Metastatic progression master regulators selected for validation.
Hypoxia is a potent microenvironmental factor promoting metastatic progression.
Together with NK cells, macrophages have a critical role in controlling metastatic progression.
Aiello, N. M. et al. Metastatic progression is associated with dynamic changes in the local microenvironment.
Oudin, M. J. et al. Tumor cell-driven extracellular matrix remodeling drives haptotaxis during metastatic progression.
b, Optimal number of clusters based on the regulators of metastatic progression for 66 liver metastases.
Addison, J. B. et al. KAP1 promotes proliferation and metastatic progression of breast cancer cells.
Paper: "Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression".
He also uncovered that the cancer cell of origin has profound impact on metastatic progression.
Li Z, Kang Y. Emerging therapeutic targets in metastatic progression: A focus on breast cancer.
Researchers are probing the consequences of these factors on tumor development, metastatic progression, and therapy response.
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