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DEJ labeling of PN643, HD1-121 and PC815 was markedly diminished in the skin specimens from the proband (Fig. 4A-C).
We report that PPAR-γ levels were markedly diminished in skin and lung biopsies from patients with SSc, and in fibroblasts explanted from the lesional skin.
We show here that PPAR-γ expression was markedly diminished in skin and lung biopsies from patients with diffuse cutaneous SSc, as well as in unstimulated fibroblasts explanted from the lesional skin.
In addition, our result as for human Treg cells was consistent with the previous report that CD25highCD4+T cells are markedly diminished in the PBMCs and salivary gland tissues from SS patients [49].
Following exposure to extracellular SMase C from S. aureus, the CFTR current was markedly diminished in a time-dependent manner.
The VSD is usually nonrestrictive and if right ventricular outflow obstruction is severe, the intracardiac shunt is from right to left and pulmonary blood flow may be markedly diminished with deoxygenated blood being pumped into circulation resulting in cyanosis.
These preferences are markedly diminished as cells mature, suggesting that programs that control differentiation state are key determinants of spatiotemporal behaviour, and thus dictate the signals a cell receives from specific microenvironmental domains.
Consistent with the fractionation assay results, BRD9 binding was markedly diminished upon inhibitor treatment (Fig. 6c).
However, quantitative analysis of mammary gland branching morphogenesis demonstrated that branching complexity is markedly diminished in the α2-deficient animals.
They markedly diminished by 8 h.
Graying was markedly diminished, although checking occurred in all specimens.
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