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Major disadvantage of cryogenic distillation is the large amount of energy required to provide the refrigeration.
American architects operate with a major disadvantage.
It puts Trump at a major disadvantage.
But the Fed also has a major disadvantage.
These totals leave him at a major disadvantage.
Against these formidable achievements must be set one major disadvantage.
These rebels are at a major disadvantage, and are unlikely to succeed without direct foreign intervention.
He starts with a major disadvantage, a shaky sign of his team's organizing abilities in Illinois.
If you weren't instantly connected, you were at a major disadvantage.
Its major disadvantage is the oversmoothing.
A major disadvantage is that the technique is computationally expensive.
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