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Ripken has made a significant difference in major league baseball.
The age of the mother made a significant difference.
One change has made a significant difference in Britain.
Sisay says improvements in HIV diagnostics have made a significant difference, particularly for monitoring pregnant women.
However, the few that have put healthy eating on the agenda have made a significant difference.
Thank you for your support, it has made a significant difference!
Organisers say the singer's bravery in speaking out has made a significant difference.
In particular, the type of water used made a significant difference.
It made a significant difference to the Mirror's headline figure of course.
"Everyone knows that Setanta has made a significant difference to the money available to the FA.
Lowe Lintas' New York campaign, he added, "has really made a significant difference in the last year".
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