Sentence examples for Loss of checkpoints from inspiring English sources

The combination of drugs altered the cell cycle with a 15% decrease in G0/G1 and a 100% increase in cells in S and G2/M phases, compared to control cells (Figure 5A) indicates loss of checkpoints in G1 and G2 ordinarily induced by acute DNA-damage.

Therefore, we hypothesize that, when CCDC6 is deleted or silenced, the loss of checkpoints and of repair accuracy [ 17] might favour genome instability and may represent an early independent event of a multistep carcinogenetic process in primary tumours.

A substantial decrease in claspin expression indicated loss of checkpoint-mediated ATR control of the cell cycle following DNA damage.

Cancer progression is believed to involve the loss of checkpoint controls that regulate normal passage through the cell cycle.

Loss of checkpoint mechanisms is frequently found in cancer, a trait which can be exploited in cancer therapy.

In our simulation of the response to SSBs, loss of checkpoint kinase 1 (Chk1) blocked one of two pathways promoting cell division cycle 25 A (Cdc25A) degradation.

The Bcl-6-mediated loss of checkpoint function may result in a potentially hazardous state of physiological genomic instability, which may cause B cells to undergo malignant transformation.

Loss of checkpoint function allows the cells to progress to mitosis despite the presence of damaged DNA, often resulting in mitotic cell death (MCD).

The synergy between mutations in p53 and the BRCA genes in tumours indicates a role for loss of checkpoint control in tumour progression.

Although the lack of specificity of this inhibiting action causes multiple unwanted side effects, cancer cells appear to be more sensitive to the effects of proteasome inhibition than normal cells due to a loss of checkpoint mechanisms occurring during tumorigenesis.

To test whether the loss of checkpoint activity in the Mad1-RLK/AAA or Bub1-cm1 mutant (Fig 1F and L) is at all related to the loss of Mad1 from kinetochores, we tested checkpoint activity after artificially recruiting Mad1 to kinetochores through fusion to the kinetochore protein Mis12 (Fig 2).