Psychophysiological interactions (PPI) analysis revealed stronger functional connectivity between LIFG and PCC for long-duration trials than for forgotten trials.
Materials forgotten during T1 were categorized as forgotten trials, and those remembered during T2 were categorized as long-duration trials.
Importantly, long-duration trials showed stronger activity in the left inferior frontal gyrus (LIFG) but less deactivation in the PCC relative to short-duration trials.
Recording gamma and high-gamma responses required a large number of experimental trials for a sufficient signal-to-noise ratio, which would not have been feasible with the long-duration trials of an active experiment within reasonable investigation time.
Randomized, controlled, long-duration trials with independent adjudication are the only way to evaluate rare side effects, as also mentioned by Kahn recently (7).
The average reaction time in long duration trials should be longer for choices involving cardinal orientations than for choices in oblique orientations, by virtue of the different number of cells involved in their representation.
If two different mechanisms for decision exist, one should observe that reaction time distributions tend to be more skewed in long duration trials, where the subject sacrifices speed for accuracy.
Leaky accumulation with a time constant τ ≈ −0.24 s would result in short trials (with a stimulus duration less than a quarter of a second) being essentially unimpaired, while long duration trials would be more strongly impaired.
However, recent long duration trials have evaluated the impact of antileukotrienes in comparison to glucocorticoids and showed that symptoms, spirometry, β2-agonist use, and also quality of life were improved to a greater extent with glucocorticoids [ 22, 23].
Although it is likely that long duration trials could provide a higher precision, the results show that LDS was responsive to footwear change despite the low number of analyzed strides.
