It is encouraging, although of limited significance, that the frequencies of significant antibody responses for two of the cancers are roughly comparable to reports in the literature.
There is also significant evidence that tumour hypoxia may be of limited significance in cancer metastasis (Rofstad, 2000).
But at least in its limited significance, formal neutrality seemed to serve some purpose.
But Mr. Trichet cautioned that these estimates were of limited significance during a time of extreme volatility.
All of this is, though, the equivalent of spring training baseball — suggestive and intriguing, but of limited significance.
Outside the legal academy, where it is generally deemed to be of limited significance, the case is little known.
On paper, both events are of limited significance in the race for the Republican presidential nomination.
It is not clear why government lawyers opted to remove the Reykjavik-13 count, though in the wider picture the move is of limited significance.
That being said, UK Coal's immediate earnings are, in our view, of limited significance, given the potential extent of the business restructuring, and the resultant impact on company valuation.
Yet, even in such sequences, the catalytic efficiencies of UNG2 and SMUG1 are much higher than those of TDG or MBD4, so the latter enzymes presumably have a limited significance in uracil-repair except in special sequence contexts.
However, widespread gene transfer by means of transduction is of limited significance because the packaging of bacterial DNA into a virus is inefficient and the bacteriophages are usually highly restricted in the range of bacterial species that they can infect.
