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Extensive efforts to develop sirtuin inhibitors have yielded many compounds with limited potency and/or selectivity, but also a few very promising substances.
Neutralizing antibody (nAb) response is sporadic and has limited potency and breadth during infection with human immunodeficiency virus type 1 (HIV-1).
However, human type II alveoli cells were not generated, which is likely due to the limited potency of the human cells and/or species difference.
From the renal point of view, since podocytes with abundant mitochondria have limited potency for regeneration, mitochondrial cytopathies induce irreversible podocyte damage and microvascular lesions, which comprise a fatal strike to kidney function.
The expression of this developmental gene might explain or at least reflect the limited potency of these lines.
This property is interesting considering that many clinically used anticancer drugs show limited potency on spheroids, possibly reflecting their limited activity on solid tumors [23], [24].
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Cells are intelligent in sensing their environment, so manipulating just one signal can limit potency and promote side-effects for therapeutics.
Air power has been a substantial advantage for President Bashar al-Assad, even as the lengthy conflict has limited the potency of some of his most powerful weapons.
"I would like states to limit the potency of the products," she said.
Antigen-independent tonic signaling by chimeric antigen receptors (CARs) can increase differentiation and exhaustion of T cells, limiting their potency.
The 30-year-old Holland international's form for Boro has earned him a recall to the international scene under Marco van Basten, and having managed to limit the potency of Frank Lampard in last weekend's 1-0 Barclays Premiership defeat at Chelsea he is determined to do the same to Liverpool's Steven Gerrard at Anfield today.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com