Limited cohort studies provide more direct evidence but still have not been able to establish a causal relationship [ 14].
However, in this limited cohort of only two cases, the tumour burden in the struma on histopathology was limited.
Second, we evaluated a limited cohort of patients, including a heterogeneous population of patients with IHCA and OHCA, which may limit the generalizability of our findings.
This scenario is further complicated by the limited cohort sizes in many NMDs, and by variations in standards of care.
These data suggest that large-scale in vivo screens are readily feasible with a limited cohort of mice – an approach that we extensively use in ongoing experiments.
The lack of a positive correlation between response and somatic mutation burden in these two pathways could be due to the limited cohort size or to aggregation of all mutations, thus masking a subset of mutations associated with clinical outcome.
The limitations of ACTG need to be acknowledged in that it will provide no information regarding the sleep architecture of patients and may be suitable only for a limited cohort of ICU patients.
But Simonson and Rosen's concept of "absolute value" only applies to a limited cohort of brands: those they classify as "O-dependent," or reliant on information services as a source of influence.
The product of these studies offers a comprehensive analysis of a limited cohort while still respecting the rules of multiple testing.
Recently, a study by our group, utilizing a high throughput mitochondrial sequencing array for the entire mitochondrial genome has demonstrated a 49% of incidence of mitochondrial mutation in head and neck squamous cell carcinoma in another limited cohort [27].
As we have shown that CSF HHV-6 IgG was elevated in non-natalizumab treated MS groups compared to CSF from patients with OND (Figure 3B), there was still a trend towards higher levels of CSF HHV-6 IgG in a subset of natalizumab treated MS patients (Figure 3B) although this did not reach statistical significance in this limited cohort.
