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Levels of complement proteins C3 and C4 were normal.
Levels of complement fractions C3 and C4 were determined by immunoturbidity.
Levels of complement components C2, C3, C6, C7, C8, and H factor were greatly elevated.
Levels of complement proteins appear to increase with aging (Waitumbi et al 2004).
Levels of complement proteins C3 and C4 were measured by nephelometry in fresh frozen plasma samples, and classical complement function was assessed by a haemolytic assay.
Levels of complement split products in amniotic fluid were determined using specific and sensitive enzyme-linked immunoassays by a technician blinded to the group assignment.
The increased number of activated microglia induced by the altered huntingtin protein most likely causes the higher levels of complement proteins in HD brains.
The initiation of BAL hemoperfusion was associated with a rapid decline in CH50 levels of complement and transient neutropenia and thrombocytopenia during all BAL exposures.
Variable levels of complement activation were detected two weeks post final boosting in RV144, which is when the V1V2 IgG correlate was identified.
Fig. 1 Brain mRNA expression levels of complement factors, complement inhibitors, and complement receptors evaluated by real-time PCR and expressed as fold changes relative to the control group.
Fig. 2 Brain expression levels of complement factors and complement inhibitors evaluated by immunoblotting, quantified by measuring band intensity with ImageJ, normalized by β-actin expression, and expressed as arbitrary units.*p < 0.05; ***p < 0.001.
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