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Further study is needed with a larger clinical sample size and we are in the process of conducting it.
As a noninvasive detection index, urine sCD163 levels may have potential clinical value, although this is yet to be proved by a larger clinical sample size.
The advantages of the present study include a larger clinical sample size with healthy controls derived from a well-characterized birth cohort and the application of age-appropriate population-derived normative data.
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The present study has several strengths such as the large (clinical) sample size, the recruitment from diverse settings, the replication in a remission group and the inclusion of several affective disorders and cognitive constructs.
The major strengths of this study are the pragmatic study design based on prospective registry data in an everyday clinical setting, large sample size, re-evaluation of preoperative magnetic resonance imaging in a large subgroup, and protocol based statistical analyses with blinded assessment of main outcome measures.
The future study would perform clinical trials on a larger scale sample size, and as a comparison study among conventional and 3D printed casts to assess whether clinical differences were statistically significant.
Further well-designed, double blinded, randomized and controlled clinical trials with larger sample size in this area are still needed.
Another double-blind placebo-controlled randomized clinical trial with larger sample size is needed to confirm these findings.
For the formal validation of the assay and its incorporation intro clinical practice, a larger sample size (ideally from distinct centers) under less controlled conditions should be used.
However, their study focused on exploring the mechanisms underlying the relationship of inflammatory process and coronary heart disease and their finding require further testing in both epidemiological and clinical studies with larger sample size.
Although the population was relatively diverse (age, years of experience, degrees, clinical setting), a larger sample size with a subset used for the qualitative analysis would have been a stronger design.
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