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Large domain movements often require an additional source of energy.
Large domain motions in enzymes are not generally regarded as gating systems.
Cas9 nuclease activity is a multistep process involving large domain movements and reorganisation3,4,5,6.
There seems to be a large domain, rich with interesting configurations of such saddle surfaces.
Ultimately PRL may be regarded as an intelligent system for formal constructive problem solving in a large domain of mathematics.
However, it is difficult to use an ontology, especially those that cover a large domain.
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The system features the use of word embeddings and lexicons, automatically derived from a large domain-specific corpus which the team constructed.
Large domain-like features and folds were seen on the C-face surfaces, but the SiC steps were not observed.
There is, however, a deficit of high-resolution large-domain assessments.
A large-domain approach is developed for calculating ship boundary layers and wakes and wave fields for nonzero Froude number.
While the frequently used process-based models can produce physically realistic simulations of ground thermal properties, their large-domain applicability at high spatial resolution is diminished by a lack of suitable data needed to realistically represent relevant processes10,13.
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