The cell traces also demonstrate that PECAM-1−/− cells move relatively short distances before changing direction, suggesting that they also lack directional persistence (Figure 2C).
MSNBC's president and general manager, Erik Sorenson, who oversaw these changes, says, "I think we've lacked directional consistency.
NCCs that are unable to respond to PDGFA have migratory defects, a reduced ability to recover from scratch assays and lack directional persistence (He and Soriano, 2013; Vasudevan and Soriano, 2014).
Quantitative comparison of gut tissue from wild-type mice and APC heterozygotes (APC Min/+; multiple intestinal neoplasia model) demonstrated that cells in precancerous epithelia lack directional preference when moving along the crypt-villus axis.
Assume, also, that he has no reason to think that others in his society have, nor that they lack, his directional ability.
The test pilots found the aircraft easy to fly, but the control forces were very high at speed and it lacked enough directional stability.
A gating mechanism for the mechanotransducer channels that lacks the directional sensitivity provided by an oblique tip link would be an alternative hypothesis, such as that proposed for inner (but not outer) hair cells in MYO15A mutant mice [46].
The feedback loop can propagate polarity across clones of cells that lack the global directional signal, although this polarity propagation is error prone.
However, this vision of mix-and-match assembly is far from being realized, not least because of the challenge in reliably predicting three-dimensional structures for molecular crystals, which lack the strong directional bonding found in networks.
The main reason for this is that HMAX lacks an appropriate directional module against rotational deformation, thereby often leading to mismatch.
