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Lack of potent single-agent activity, when using in vivo tumor growth as an efficacy measure, lends support to the belief that ILK inhibitors must be developed in the context of other therapeutics.
In fairness he is not the only one who must shoulder the responsibility for Chelsea's goalscoring inhibitions, but the lack of potent alternatives is not helping matters.
However, pharmacological interrogation of Eph kinase function has been hampered by a lack of potent and selective Eph kinase inhibitors.
To date, pharmacological characterization of GPR88 has been limited due to the lack of potent and selective agonists and antagonists appropriate for CNS investigations.
However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wide therapeutic potential of rhomboids is currently untapped.
mSWI/SNF-deficient cancers remain a therapeutic challenge, owing to a lack of potent and selective agents which target complexes or unique pathway dependencies generated by mSWI/SNF subunit perturbations.
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Thanks to the lack of commercially potent new titles, takings overall are 42% down on the previous frame.
Due to the relative lack of commercially potent new releases, takings are 14% down on the previous weekend.
Also helping was a notable lack of commercially potent new releases, with Ghost Rider 3D: Spirit of Vengeance (£1.34m) the only debutant in the top 10.
Methadone's delayed narcotic effect and its lack of a potent high are important reasons the drug can be so dangerous, experts say.
Click to view With August bank holiday Monday falling the previous weekend, the 29-31 Auguslotlot didn't prove a particularly attractive option for distributors, as evidenced by a lack of commercially potent new titles.
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