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Because of the lack of mutation carriers in the CH patients we did not proceed with genotyping of the controls.
The lack of mutation within TP53, previously reported as strongly associated with chromothripsis in AML [ 6], further reinforced this conclusion.
Similarly lack of mutation at np 11083 in one of our samples is also treated as reversion event.
The inclusion of RAD51C gene in routine clinical testing is a controversial matter, mainly due to its low incidence or lack of mutation identification in particular populations.
The mutation is suspected to be de novo, due to the lack of family cancer history and the lack of mutation in the parent tested.
The four WBCs studied from the same patient showed the wild-type TP53 allele, indicating lack of mutation in the germline DNA.
Similar(47)
These investigations are not only being used to accurately infer abnormal proteins from known genetic mutations, but for the evaluation of tumors that have aberrant oncoproteins despite the lack of mutations.
The lack of mutations in the TP73 gene in cancers and the developmentally abnormal phenotype of the TP73 knockout mouse suggest a different function for TP73 gene derived proteins.
However, the lack of mutations in LRP1 [2] indicate important functions that have diverged from those of LRP1b.
This lack of mutations that have achieved fixation might be partly due to coexistence of beneficial mutants.
The reason for a reduced dimer formation of Bet v 1d is less clear because of a lack of mutations on the putative monomer-monomer interface.
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