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Since the L157A optineurin is still capable of interacting with itself (Fig. 7A), the lack of foci formation in L157A optineurin-GFP-expressing cells, in comparison to the wild type and the E50K counterparts, may be related to the perturbed binding of this mutant to Rab8 (Fig. 7B) and TfR (Fig. 7C) and perhaps other as-yet-unknown leucine zipper-binding protein(s) as well.
Similar(59)
"There's definitely a lack-of-focus issue," she added.
NIMH had the same lack-of-focus problems that SAMHSA and CMHS have.
Lack of focus should not be confused with support for the war.
"It was a lack of focus, lack of intensity.
It suffers from a lack of focus".
Some people say it's a lack of focus.
We had a lack of focus and concentration.
It's down to a lack of focus and leadership".
But the most important problem was a lack of focus.
Rather it is a lack of focus and priority.
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