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Methodological issues (discussed below) prohibited either the meta-analysis of, or dissemination of results from the three trials, which reported data on local disease control or the distant metastasis-free interval.
We probably underestimated the risk of hip fracture among the oldest old because of two methodological issues discussed below: the lack of clinical information (confounding factors could not be adjusted for) and the systematic misclassification of the highly exposed [ 27] nursing home patients as drug non-users.
Secondly, while clearly there are issues (discussed below) in using risk functions in PM2.5 from outdoor air to quantify the effects of indoor air pollution, doing so allows quantification of a much wider range of health outcomes than would be possible from the much more limited evidence base linking indoor air pollution and health.
A secure MCPS system must address the issues discussed below.
"If you do not feel comfortable lobbying on these issues or cannot support the positions being taken, you should not participate in this event," the email stated, urging students to contact one of the fraternity groups' lobbyists if they "are not comfortable with the positions and issues discussed below or have any questions about the priorities".
These categories are not exclusive, however, and some of the issues discussed below fit under more than one heading.
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Callicott et al. call for a better integration of these different perspectives, an issue discussed below in the section on Integrating Process and Elements Perspectives.
A more problematic issue, discussed below, is the accurate measurement of the living wage in these MSAs/CMSAs, in cases where living wages are in place in only some cities in the MSA/CMSA, or differ across them.
(Strictly speaking, these data are equally compatible with the hypothesis that cells in the later stages of carcinogenesis exert a malign influence on the surrounding, normal tissues, an issue discussed below).
Whether or not the current "boundarylessness" of the internet is desirable is a hotly contested issue discussed below.
This stylistic aspect of the turn is an issue discussed below.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com