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Questions that come to mind when I look at a piece of garment are: Is it functional?
"Well, I have just... very broadly the first thing that comes to mind, I mean, is does that patient have any respiratory disease or cardiac disease, are they anaemic or is it functional?" (SPR-1) Worryingly, no group reported an overt strategy for arriving at a diagnosis and junior trainees tended to rely on their knowledge of what was most common to deduce what was most probable.
From the mechanistic standpoint, we face two problems: first, if binding is at different sites, is it functional or nonfunctional, and second, if at similar sites, what is the outcome, activation or inhibition?
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Is it a functional form of depression?
Is it everyday functional, special occasion, or something less specific?
At this point, we must ask ourselves, what is the aim of ENCODE: Is it to identify every possible functional element at the expense of increasing the number of elements that are falsely identified as functional?
I call it functional football intelligence.
Both suggest that MHC class I is functional.
Is Congress functional or dysfunctional?
With this scaffold we built an in silico draft by mapping known enzyme-encoding genes, using gene homology information obtained from Génolevures protein families [ 8, 9] and complemented with other in silico methods, and filled network gaps in order to make it functional (i.e. to be able to predict growth from available metabolites in the media).
While we can only speculate on the exact function of Png2p and the functional significance of the repeat region, the fact that PNG2 is transcribed and that the protein is under purifying selection are evidence that Png2p contributes to C. albicans' fitness, i.e. that it is a functional repeat-containing protein.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com