Sentence examples for Irreversible commitment from inspiring English sources

States of commitment are sometimes described as "specification" to represent a reversible type of commitment and as "determination" to represent an irreversible commitment.

Down-regulation of membrana granulosa cell gap junctions is correlated with irreversible commitment to resume meiosis in golden Syrian hamster oocytes.

Assuming military leaders went along with it, the decision to leave Mr. Suleiman in place suggests no irreversible commitment to move toward democracy.

What is even more extraordinary is that, as the Lib Dems are pointing out, within the terms of the coalition agreement of 2010 the Conservatives themselves conceded a review of options short of a full-scale replacement for Trident, and accepted a delay until 2016 of the so-called "maingate" decision – the irreversible commitment to replace the continuous deterrent.

Subdividing the intrinsic pathway into three modules (initiator, amplifier, executioner), we use computer simulation and bifurcation theory to attribute signal threshold and time delay to positive feedback in the initiator module and irreversible commitment to positive feedback in the executioner module.

To this end, we propose a mathematical model of the intrinsic apoptotic pathway that captures three key dynamical features: a signal threshold to elicit cell death, irreversible commitment to the response, and a time delay that is inversely proportional to signal strength.

They make public and irreversible commitments using apps like Beeminder and StickK, which forfeit users' money when goals are missed.

Sometimes companies must make decisions about innovations that involve high up-front investments and irreversible commitments; they have to make preemptive bets.

"The point is to identify oversights and flaws before important (and often irreversible) commitments of time and resources have been made," Spear said.

We need to bridge the immediate financial gap without making quick – and ill-considered – irreversible commitments that will hamstring future solutions.

Earlier this month, the impasse led five leading Dutch economists to write a joint appeal to the country's "quarrelling politicians", urging them to split their differences and agree on a stimulus plan now, offset by "irreversible" commitments to austerity later.Visiting The Hague, one quickly hears that the country is small and crowded, with tough environmental laws.