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Not an insignificant question, either.
Many annotation pipelines would regard such a hit as insignificant, because E-values of this magnitude are often obtained purely by chance when longer query sequences are used.
However, using AvrB as a sequence query with the sensitive profile-based homology detection method COMPASS [22], [23] identified an insignificant hit (E-value 5) to the fic domain structure (3cuc).
Despite the insignificant PHI-BLAST scores, all identified fragments had a high sequence identity (>30%) with the query sequence.
No sentence is too insignificant for him to try to insert the word "fuck" into, up to and including responding to a query about whether he minds if you smoke while interviewing him: "I couldn't give a fucking shit!" he cries.
That's not insignificant.
Not an insignificant difference.
Query: huh?
Agriculture is relatively insignificant.
He is insignificant.
"That isn't insignificant".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com