Considering the power-heat-transport nexus, integrated models nowadays play a decisive role in providing insight into different flexibility options [25], using excess electricity economically [26], and for meeting climate goals [27].
It is a useful tool to gain an insight into network flexibility.
These studies highlight the scope of latent activities harbored within existing genomes and provide insight into the flexibility of modern metabolism.
Specifically, it was shown that the RCD results from the VPG provide quantitative insight into protein flexibility that is consistent within statistical error bars of the PG sample averaged over 1000 distinct constraint topologies.
Specific DARPins (designed ankyrin-repeat proteins) have been generated recognizing the phosphorylated active or unphosphorylated inactive form of ERK2 (extracellular-signal-regulated kinase 2), providing insight into the flexibility of the activation loop in the phosphorylated compared with the non-phosphorylated form [ 47].
Structural biology is providing insights into the flexibility of the PI3Ks, and providing basis for understanding the effects of mutations, drug resistance and specificity.
This approach allowed us to obtain fundamental new insights into directional flexibility in nucleic acids that enable their structures to change in a very specific functional manner.
Insights into the flexibility of the allosteric binding pocket confirm earlier hypotheses: A comparison of dualsteric hybrid structures proves the crucial role of the tropane ring system for the arrangement of the allosteric part of the ligands.
The ensembles provide insights into the flexibility of the protein residues and the ligand moieties in the complex.
Overall, our study provides novel insights into the flexibility with which human decision makers choose between speed and accuracy of their choices.
Nevertheless, it has been demonstrated that NMR ensembles may provide valuable insights into protein flexibility that is of practical use in structure-to-function studies (Bolstad and Anderson, 2008; Damm and Carlson, 2007; Isvoran et al., 2011; Knegtel et al., 1997).
