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It only considered relatively small (<28 non-hydrogen atoms) and inflexible (<6 rotatable bonds) chemical structures and would not compute any shape similarity value when there was no common reference shape.
Shylock's inflexible insistence on the bond he made with Antonio for a pound of flesh were the 3,000 ducats not repaid -- that's to say, Shylock's unrelenting stance as a broader revenge on the Christians who've tormented him throughout life as a usurer -- is decidedly matched by his tormenters' virulent prejudice.
In diamonds, the bonds form an inflexible three-dimensional lattice, whereas in graphite, the atoms are tightly bonded into sheets, which can slide easily over one another, making the overall structure weaker.
Inflexible set of data fields associated with each event.
Two-point H-bond connections are inherently inflexible in their geometry and lie within a small PIXEL energy range (−45.7 to −49.7 kJ mol−1).
Bonds can be expensive and inflexible for borrowers.
The availability of three carbonyl groups per molecule enables various H-bond connectivity modes, whereas the inflexible arrangement of the D and A functionalities within the 2,4,6(1H,3H -pyrimidinetrione unit predetermines the geometry of the resulting H-bonded structures.
For example, a S444C mutation in the CH3 domain of an IgG yielded tail-to-tail linked IgG dimers, and a S119C mutation in the CH1 domain yielded a compact, inflexible IgG as a result of an extra disulfide bond between the two heavy chains.
Requirements to amortize unfunded pension liabilities may be relatively flexible obligations that can be smoothed over time, while the POB is an inflexible debt with required annual payments.And of course, regular readers will know that financial economists regard pensions as bond-like obligations.
Indonesia is similarly inflexible.
"No, he's inflexible".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com