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Coupling the shift behavior explained above with the models, we compare awareness/attention index of agents with quality of regional density information.
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The present research focuses on the role of p21 in tumor cell response to treatment with cytotoxic agents, and on the possibility to improve the therapeutic index of such agents by modulating p21 status by p53-dependent and independent pathways.
In response to this, the attention index of regular agents for information c may increase along with incrementing the social currency of social agents who are assisting them.
Muller, G. & Kramer, A. Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity.
An enduring challenge in the field is to improve the therapeutic index of these agents.
Prodrugs are being designed to favourably alter the therapeutic index of these agents by improving their efficacy and reducing toxicity.
Poly (ethylene glycol)s (PEGs) are potential drug carriers for improving the therapeutic index of anticancer agents.
Minute amounts of tumor vasculature-targeted TNFα was reported to increase endothelial permeability, thereby accelerating drug penetration and increasing the therapeutic index of chemotherapeutic agents.
Efforts are ongoing to improve the therapeutic index of anticancer agents, either by increasing the drug concentration inside the tumor or by decreasing it in normal host tissues [10].
These transductional retargeting strategies, whereby Ad viruses are designed to selectively infect target cells, have the potential for reducing deleterious side effects and increasing the therapeutic index of these agents.
Various different tumour-targeted nanomedicines have been evaluated over the years, and clear evidence is currently available for substantial improvement of the therapeutic index of anticancer agents.
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