Sentence examples for Inactive configuration from inspiring English sources

The observation that hypomethylation correlates with a DNaseI hypersensitive site near the core promoter is consistent with evidence that DNA methylation contributes to gene silencing by attracting chromatin inactivation complexes promoting chromatin condensation into an inactive configuration (2, 4).

Initially, the probe remained in the inactive configuration.

Single-molecule imaging and X-ray crystallography studies now demonstrate that the aminoglycoside antibiotic neomycin binds to ribosomal RNA within the large subunit to allosterically control ribosomal subunit rotation and stabilize an inactive configuration of the ribosome.

Consistent with the conclusions of previous studies [9], [31], this result suggests that the vast majority of the protease is normally in the closed, inactive configuration.

In the cardiac myocyte this might be achieved through the clamping of inhibitory src kinases in an inactive configuration by Cav [14] [17].

In mammalian cells, methylation of DNA helps stabilize chromatin in an inactive configuration and inhibits gene transcription (14- 16).

Furthermore, it has been postulated that Eph receptor dimers can switch between active and inactive configurations through a rotation coupling activation mechanism, and indeed recent mutational experiments highlighted more or less activated forms of the dimer compared to the wild-type EphA2 receptor in both ligand-dependent and -independent configurations.

Several studies have indicated that the S/S-SAMe configuration is the "active" form involved in methyltransferase catalyzed reactions [ 34]'[ 35]'[ 36] and that the R/S-SAMe configuration is the biologically "inactive" form as it may inhibit methyltransferases reactions [ 37].

EZH2 represses gene expression through H3K27me3, leading to an inactive chromatin configuration [18].

The chromatin environment in centromeres is different from the usual active and inactive chromatin configuration.

These properties suggest that a crystal structure of the Axl ectodomain bound to Gla-less Gas6 (Sasaki et al., 2006) represents a ligand-occupied but inactive Axl configuration.