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In TRAIL resistant breast T47D cells, overexpression of the mutant PTEN further increased their resistance to TRAIL.
In trail 1, animals administrated with particle bombardment induced better protective efficacy.
In trail 2, the levels of specific IgG antibodies against SjTGR were detected by ELISA following standard methods [ 32].
Thus, our results suggest that activation of Akt/mTOR pathway is a common event in TRAIL resistant cancer cell lines and that this pathway may be important in TRAIL resistance.
Someone could really give a lesson in trail building here".
He was sensational in trail technique and outside press.
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Since overexpression of DR5 in TRAIL-resistant cancer cells restored TRAIL sensitivity.
However, TRAIL only works in TRAIL-sensitive tumors and most tumor cells often exhibit a TRAIL-resistance phenotype, which is currently a major obstacle in TRAIL-based cancer therapy [12], [13], [14].
However, nuclear fragmentation was absent and it was very infrequent in TRAIL-treated cells.
We now investigate the intracellular mechanisms involved in TRAIL-induced cell proliferation.
These results highlight the main role of Akt in TRAIL-mediated proliferation.
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