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In this prognosis study, we excluded 71 patients, including 32 who had incomplete clinical information or failed follow-up, 13 who died within 2 months after surgery, 17 patients with metastatic diseases, and nine with recurrence within 1 month after surgery.
One can only hope that in this prognosis, as in his political ones, his pessimism is unwarranted.
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However, with still a year to go till the midterms and another budget battle looming in January, this prognosis is premature.
It is postulated that the low probability of E2F pathway deregulation, in the context of PI3K, Myc and β-catenin pathway deregulation, is promoting tumorigenesis in this poor prognosis subset of young women with breast cancer.
Further investigation in combination with other active agents in this poor prognosis group is appropriate.
In this good prognosis group, 60 out of 167 (36%) had a Gleason grade ⩾7.
Three-year survival was >60% in this poor prognosis group of patients.
Further evaluation of the combination of chemotherapy and radiotherapy may be useful in this poor prognosis group.
A gene set related to P53 mutation was also enriched in this bad prognosis subtype in the watchful waiting cohort, but not in the other cohort.
However, there were insufficient patients in this good prognosis sub-group for such an approach to be confirmed in the present study.
Overall, 43% of cases were less than 1 mm at diagnosis, but the proportion in this good prognosis category has increased significantly over time.
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CEO of Professional Science Editing for Scientists @ prosciediting.com