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Both characterized P450s acting in this pathways, allene oxide synthase (AOS, CYP74A) and hydroperoxide lyase (HPL1, CYP74B2) [ 19], were correctly placed in the pathways 'jasmonic acid biosynthesis' (TAIR-GO) and 'lipoxygenase pathway' (AraCyc), respectively.
It has been reported in [ 42] that the expression of one of the key genes involved in this pathways, GJA1, which encodes the connexin43 protein, is reduced in human and mouse lung carcinoma cells.
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PARP1 could be part of a complex in this pathway or proteins in this pathway are PARylated.
In this pathway p73 is an important immediate downstream effector.
The Rich factor is the ratio of DEGs numbers annotated in this pathway term to all gene numbers annotated in this pathway term.
In this pathway, Na+ is stabilized in the intermediate state through interactions with the available E428.
RichFactor is the ratio of the consistent SDE genes annotated in a pathway to all the genes in this pathway.
As such, genes in this pathway should be carefully evaluated in patients with ID and macrocephaly.
When individuals are born with mutations in this pathway, they often have severe developmental defects.
Although Krebs elucidated most of the reactions in this pathway, there were some gaps in his design.
In addition, we tested for mRNA expression of two important receptor proteins in this pathway, C3aR and C5aR.
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