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In this dosing schedule, Belinostat is not active as monotherapy, suggesting further investigations of different dosing schedules or in combination with other chemotherapeutics.
The patients in this dosing scheme were in the double-dose (2D) group.
In most patients, only minor corrections in this dosing were necessary (3.5 to 4.2 mmol/L) to achieve calcium levels of 0.25 to 0.35 mmol/L in the blood of the extracorporeal circuit.
Although the current study was not designed and not powered to show that EPO did not increase mortality in this dosing scheme and that EPO was safe, the number of patients who died during the study period was one in the EPO group and none in the placebo group.
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Taken together, these findings suggest that gaboxadol, when administered in this dose, is an effective hypnotic, in that it improves sleep, without producing adverse or residual effects in elderly people.
We aimed to assess overall safety and preliminary activity in this dose-escalation study of CUDC-907 monotherapy in patients with relapsed or refractory lymphoma and multiple myeloma.
We concluded that salvage gemcitabine in this dose and schedule is safe and tolerable in previously platinum-treated patients with NSCLC.
A total of 20 children aged 7 months to 7 years were enrolled in this dose-escalation study, after baseline seizure frequencies were established.
The dose-response curve for the induction of complex-type exchanges by heavy ions was linear in the dose-range 0.2-1.5 Gym while γ-rays did not produce a significant increase in the yield of complex rearrangements in this dose range.
There was, however, considerable spread in this dose-response relationship.
This study failed to show a priming effect for rG-CSF when given in this dose and schedule.
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